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B, Trichrome stain of mature scar, showing dense collagen, with solely scattered vascular channels. Somatic cell mutation can create a genetic variation in a cell population which can induce cancer and tumour when such mutation takes place in repressor genes controlling cell cycles similar to p53 gene. Other much less widespread organisms are Streptococcus pyogenes, Staphylococcus aureus, gram adverse enteric bacteria, and anaerobes (5) blood pressure unsafe levels discount 5 mg warfarin amex.